Update on the Mechanism and Treatment of Sevoflurane-Induced Postoperative Cognitive Dysfunction

Cong-mei Wang; Wei-can Chen; Yan Zhang; Shu Lin; Shu Lin; Shu Lin; He-fan He

doi:10.3389/fnagi.2021.702231

Frontiers in Aging Neuroscience (Jul 2021)

Update on the Mechanism and Treatment of Sevoflurane-Induced Postoperative Cognitive Dysfunction

Cong-mei Wang,
Wei-can Chen,
Yan Zhang,
Shu Lin,
Shu Lin,
Shu Lin,
He-fan He

Affiliations

Cong-mei Wang: Department of Anesthesiology, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, China
Wei-can Chen: Department of Anesthesiology, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, China
Yan Zhang: Department of Anesthesiology, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, China
Shu Lin: Department of Anesthesiology, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, China
Shu Lin: Diabetes and Metabolism Division, Garvan Institute of Medical Research, Darlinghurst, Sydney, NSW, Australia
Shu Lin: Centre of Neurological and Metabolic Research, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
He-fan He: Department of Anesthesiology, The Second Affiliated Hospital, Fujian Medical University, Quanzhou, China

DOI: https://doi.org/10.3389/fnagi.2021.702231
Journal volume & issue: Vol. 13

Abstract

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Sevoflurane is one of the most widely used anesthetics for the induction and maintenance of general anesthesia in surgical patients. Sevoflurane treatment may increase the incidence of postoperative cognitive dysfunction (POCD), and patients with POCD exhibit lower cognitive abilities than before the operation. POCD affects the lives of patients and places an additional burden on patients and their families. Understanding the mechanism of sevoflurane-induced POCD may improve prevention and treatment of POCD. In this paper, we review the diagnosis of POCD, introduce animal models of POCD in clinical research, analyze the possible mechanisms of sevoflurane-induced POCD, and summarize advances in treatment for this condition.

Published in Frontiers in Aging Neuroscience

ISSN: 1663-4365 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.frontiersin.org/journals/aging-neuroscience

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