Serum Phospholipids Fatty Acids and Breast Cancer Risk by Pathological Subtype
Virginia Lope,
Ángel Guerrero-Zotano,
Ana Casas,
José Manuel Baena-Cañada,
Begoña Bermejo,
Beatriz Pérez-Gómez,
Inmaculada Criado-Navarro,
Silvia Antolín,
Pedro Sánchez-Rovira,
Manuel Ramos-Vázquez,
Antonio Antón,
Adela Castelló,
José Ángel García-Saénz,
Montserrat Muñoz,
Ana de Juan,
Raquel Andrés,
Antonio Llombart-Cussac,
Blanca Hernando,
Rosa María Franquesa,
Rosalia Caballero,
Feliciano Priego-Capote,
Miguel Martín,
Marina Pollán
Affiliations
Virginia Lope
Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, 28029 Madrid, Spain
Ángel Guerrero-Zotano
GEICAM Spanish Breast Cancer Group, 28703 Madrid, Spain
Ana Casas
GEICAM Spanish Breast Cancer Group, 28703 Madrid, Spain
José Manuel Baena-Cañada
GEICAM Spanish Breast Cancer Group, 28703 Madrid, Spain
Begoña Bermejo
GEICAM Spanish Breast Cancer Group, 28703 Madrid, Spain
Beatriz Pérez-Gómez
Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, 28029 Madrid, Spain
Inmaculada Criado-Navarro
Analytical Chemistry Department, Universidad de Córdoba, 14071 Córdoba, Spain
Silvia Antolín
GEICAM Spanish Breast Cancer Group, 28703 Madrid, Spain
Pedro Sánchez-Rovira
GEICAM Spanish Breast Cancer Group, 28703 Madrid, Spain
Manuel Ramos-Vázquez
GEICAM Spanish Breast Cancer Group, 28703 Madrid, Spain
Antonio Antón
GEICAM Spanish Breast Cancer Group, 28703 Madrid, Spain
Adela Castelló
Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, 28029 Madrid, Spain
José Ángel García-Saénz
GEICAM Spanish Breast Cancer Group, 28703 Madrid, Spain
Montserrat Muñoz
GEICAM Spanish Breast Cancer Group, 28703 Madrid, Spain
Ana de Juan
GEICAM Spanish Breast Cancer Group, 28703 Madrid, Spain
Raquel Andrés
GEICAM Spanish Breast Cancer Group, 28703 Madrid, Spain
Antonio Llombart-Cussac
GEICAM Spanish Breast Cancer Group, 28703 Madrid, Spain
Blanca Hernando
GEICAM Spanish Breast Cancer Group, 28703 Madrid, Spain
Rosa María Franquesa
GEICAM Spanish Breast Cancer Group, 28703 Madrid, Spain
Rosalia Caballero
GEICAM Spanish Breast Cancer Group, 28703 Madrid, Spain
Feliciano Priego-Capote
Analytical Chemistry Department, Universidad de Córdoba, 14071 Córdoba, Spain
Miguel Martín
GEICAM Spanish Breast Cancer Group, 28703 Madrid, Spain
Marina Pollán
Cancer and Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, 28029 Madrid, Spain
This study evaluates whether serum phospholipids fatty acids (PL-FAs) and markers of their endogenous metabolism are associated with breast cancer (BC) subtypes. EpiGEICAM is a Spanish multicenter matched case-control study. A lifestyle and food frequency questionnaire was completed by 1017 BC cases and healthy women pairs. Serum PL-FA percentages were measured by gas chromatography-mass spectrometry. Conditional and multinomial logistic regression models were used to quantify the association of PL-FA tertiles with BC risk, overall and by pathological subtype (luminal, HER2+ and triple negative). Stratified analyses by body mass index and menopausal status were also performed. Serum PL-FAs were measured in 795 (78%) pairs. Women with high serum levels of stearic acid (odds ratio (OR)T3vsT1 = 0.44; 95% confidence interval (CI) = 0.30–0.66), linoleic acid (ORT3vsT1 = 0.66; 95% CI = 0.49–0.90) and arachidonic to dihomo-γ-linolenic acid ratio (OR T3vsT1 = 0.64; 95% CI = 0.48–0.84) presented lower BC risk. Participants with high concentrations of palmitoleic acid (ORT3vsT1 = 1.65; 95% CI = 1.20–2.26), trans-ruminant palmitelaidic acid (ORT3vsT1 = 1.51; 95% CI = 1.12–2.02), trans-industrial elaidic acid (ORT3vsT1 = 1.52; 95% CI = 1.14–2.03), and high oleic to stearic acid ratio (ORT3vsT1 = 2.04; 95% CI = 1.45–2.87) showed higher risk. These associations were similar in all BC pathological subtypes. Our results emphasize the importance of analyzing fatty acids individually, as well as the desaturase activity indices.