Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c

Hongrui Meng; Chikara Yamashita; Kahori Shiba-Fukushima; Tsuyoshi Inoshita; Manabu Funayama; Shigeto Sato; Tomohisa Hatta; Tohru Natsume; Masataka Umitsu; Junichi Takagi; Yuzuru Imai; Nobutaka Hattori

doi:10.1038/ncomms15500

Nature Communications (Jun 2017)

Loss of Parkinson’s disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c

Hongrui Meng,
Chikara Yamashita,
Kahori Shiba-Fukushima,
Tsuyoshi Inoshita,
Manabu Funayama,
Shigeto Sato,
Tomohisa Hatta,
Tohru Natsume,
Masataka Umitsu,
Junichi Takagi,
Yuzuru Imai,
Nobutaka Hattori

Affiliations

Hongrui Meng: Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine
Chikara Yamashita: Department of Neurology, Juntendo University Graduate School of Medicine
Kahori Shiba-Fukushima: Department of Treatment and Research in Multiple Sclerosis and Neuro-intractable Disease, Juntendo University Graduate School of Medicine
Tsuyoshi Inoshita: Department of Treatment and Research in Multiple Sclerosis and Neuro-intractable Disease, Juntendo University Graduate School of Medicine
Manabu Funayama: Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine
Shigeto Sato: Department of Neurology, Juntendo University Graduate School of Medicine
Tomohisa Hatta: Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology
Tohru Natsume: Molecular Profiling Research Center for Drug Discovery, National Institute of Advanced Industrial Science and Technology
Masataka Umitsu: Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University
Junichi Takagi: Laboratory of Protein Synthesis and Expression, Institute for Protein Research, Osaka University
Yuzuru Imai: Department of Neurology, Juntendo University Graduate School of Medicine
Nobutaka Hattori: Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine

DOI: https://doi.org/10.1038/ncomms15500
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 18

Abstract

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Mutations inCHCHD2 are associated with Parkinson’s disease. Here the authors investigate the physiological and pathological roles of CHCHD2 in Drosophilaand mammalian cells, and find that it regulates mitochondrial respiration through stabilizing cytochrome c.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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