Brain Sciences (Aug 2022)

Retrospective Multicenter Study on Outcome Measurement for Dyskinesia Improvement in Parkinson’s Disease Patients with Pallidal and Subthalamic Nucleus Deep Brain Stimulation

  • Fangang Meng,
  • Shanshan Cen,
  • Zhiqiang Yi,
  • Weiguo Li,
  • Guoen Cai,
  • Feng Wang,
  • Stephan S. Quintin,
  • Grace E. Hey,
  • Jairo S. Hernandez,
  • Chunlei Han,
  • Shiying Fan,
  • Yuan Gao,
  • Zimu Song,
  • Junfei Yi,
  • Kailiang Wang,
  • Liangwen Zhang,
  • Adolfo Ramirez-Zamora,
  • Jianguo Zhang

DOI
https://doi.org/10.3390/brainsci12081054
Journal volume & issue
Vol. 12, no. 8
p. 1054

Abstract

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Deep brain stimulation (DBS) is an effective treatment for dyskinesia in patients with Parkinson’s disease (PD), among which the therapeutic targets commonly used include the subthalamic nucleus (STN) and the globus pallidus internus (GPi). Levodopa-induced dyskinesia (LID) is one of the common motor complications arising in PD patients on chronic treatment with levodopa. In this article, we retrospectively evaluated the outcomes of LID with the Unified Dyskinesia Rating Scale (UDysRS) in patients who underwent DBS in multiple centers with a GPi or an STN target. Meanwhile, the Med off MDS-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS-Ⅲ) and the levodopa equivalent daily dose (LEDD) were also observed as secondary indicators. PD patients with a GPi target showed a more significant improvement in the UDysRS compared with an STN target (92.9 ± 16.7% vs. 66.0 ± 33.6%, p 0.0001). Both the GPi and the STN showed similar improvement in Med off UPDRS-III scores (49.8 ± 22.6% vs. 52.3 ± 29.5%, p = 0.5458). However, the LEDD was obviously reduced with the STN target compared with the GPi target (44.6 ± 28.1% vs. 12.2 ± 45.8%, p = 0.006).

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