Nature Communications (Nov 2017)

Role of epithelial to mesenchymal transition associated genes in mammary gland regeneration and breast tumorigenesis

  • Shaheen S. Sikandar,
  • Angera H. Kuo,
  • Tomer Kalisky,
  • Shang Cai,
  • Maider Zabala,
  • Robert W. Hsieh,
  • Neethan A. Lobo,
  • Ferenc A. Scheeren,
  • Sopheak Sim,
  • Dalong Qian,
  • Frederick M. Dirbas,
  • George Somlo,
  • Stephen R. Quake,
  • Michael F. Clarke

DOI
https://doi.org/10.1038/s41467-017-01666-2
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 9

Abstract

Read online

The contribution of EMT in mammary gland homeostasis and human breast cancer is still unclear. Here, using in vivo lineage tracing and breast cancer PDXs the authors demonstrate that the repopulating capacity in normal mammary epithelial cells and tumorigenic capacity in breast cancer is independent of expression of EMT-associated genes.