SPossibilities of 4-Component Therapy in Renal Protection: UNIKUM Trial Results

Abstract

There are given the results of first in Ukraine experience of 4-component therapy (angiotensin II receptor blockers, β-blocker, acetylsalicylic acid, statin) — multimodal strategy under randomized study in patients with chronic renal disease. Convincing data on decrease of blood pressure, microalbuminuria and improvement of lipid profile at positive dynamics of glomerular filtrate rate are obtained. In comparison with efficacy of fixed combination (polypill) there was assessed advisability of this regimen in patients with chronic renal disease, asl well as marketing opportunity of generic polypill creation in Ukraine.

Keywords

• 4-component therapy, UNIKUM, fixed combination, polypill, efficiency of combined therapy