mSphere of Influence: Deciphering purine auxotrophy in protozoan parasites

Abstract

ABSTRACTBruno Martorelli Di Genova works in parasitology, focusing on Toxoplasma gondii metabolism. In this mSphere of Influence article, he reflects on how the articles “Metabolic Reprogramming during Purine Stress in the Protozoan Pathogen Leishmania donovani” and “Yeast-Based High-Throughput Screen Identifies Plasmodium falciparum Equilibrative Nucleoside Transporter 1 Inhibitors That Kill Malaria Parasites” impacted him, informing his research strategies and understanding of metabolic flexibility in Toxoplasma gondii.

Keywords

• apicomplexan parasites
• purine metabolism
• protozoa
• Leishmania
• Plasmodium falciparum