Carbodefluorination of fluoroalkyl ketones via a carbene-initiated rearrangement strategy

Linxuan Li; Xinyu Zhang; Yongquan Ning; Xiaolong Zhang; Binbin Liu; Zhansong Zhang; Paramasivam Sivaguru; Giuseppe Zanoni; Shuang Li; Edward A. Anderson; Xihe Bi

doi:10.1038/s41467-022-31976-z

Nature Communications (Jul 2022)

Carbodefluorination of fluoroalkyl ketones via a carbene-initiated rearrangement strategy

Linxuan Li,
Xinyu Zhang,
Yongquan Ning,
Xiaolong Zhang,
Binbin Liu,
Zhansong Zhang,
Paramasivam Sivaguru,
Giuseppe Zanoni,
Shuang Li,
Edward A. Anderson,
Xihe Bi

Affiliations

Linxuan Li: Department of Chemistry, Northeast Normal University
Xinyu Zhang: Department of Chemistry, Northeast Normal University
Yongquan Ning: Department of Chemistry, Northeast Normal University
Xiaolong Zhang: Department of Chemistry, Northeast Normal University
Binbin Liu: Department of Chemistry, Northeast Normal University
Zhansong Zhang: Department of Chemistry, Northeast Normal University
Paramasivam Sivaguru: Department of Chemistry, Northeast Normal University
Giuseppe Zanoni: Department of Chemistry, University of Pavia
Shuang Li: Department of Chemistry, Northeast Normal University
Edward A. Anderson: Chemistry Research Laboratory, University of Oxford
Xihe Bi: Department of Chemistry, Northeast Normal University

DOI: https://doi.org/10.1038/s41467-022-31976-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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The selective functionalization of trifluoromethyl groups is challenging due to the inertness of the C–F bonds. Here the authors report a method for the carbodefluorination of C–F bonds of fluoroalkyl ketones via a carbene-initiated rearrangement strategy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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