Co-regulatory network of transcription factor and microrna: A key player of gene regulation

Abstract

Transcription factor (TF) and microRNA (miRNA) interaction plays a vital role in the regulation of biological networks. TFs and miRNAs control the gene expression: TF at transcriptional level by affecting the messenger RNA (mRNA) transcription and miRNA at posttranscriptional level by affecting the transcription and translation. Furthermore, sometimes, both miRNAs and TFs regulate one another's expressions; as a consequence, this may influence the expression of the target gene. In order to understand the main co-regulatory mechanisms underlying, it is important to identify biologically relevant network motifs involving TFs, miRNAs and their targets. The present study focuses on TF, miRNA and target gene interactions.

Keywords

• disease
• genes
• messenger rna
• microrna
• posttranscription level
• transcription factor