Generation of a hiPSC line ZZUNEUi007-A from a patient with hypertrophic cardiomyopathy caused by mutation in MYH7

Xiaowei Li; Yangyang Liu; Feifei Liu; Xiaojuan Wang; Mengduan Liu; Wenting Du; Jing Zhao; Mengyu Wang; Liang Hu; Chuchu Wang; Wanrong Fu; Jianzeng Dong; Xiaoyan Zhao

Stem Cell Research (Mar 2020)

Generation of a hiPSC line ZZUNEUi007-A from a patient with hypertrophic cardiomyopathy caused by mutation in MYH7

Xiaowei Li,
Yangyang Liu,
Feifei Liu,
Xiaojuan Wang,
Mengduan Liu,
Wenting Du,
Jing Zhao,
Mengyu Wang,
Liang Hu,
Chuchu Wang,
Wanrong Fu,
Jianzeng Dong,
Xiaoyan Zhao

Affiliations

Xiaowei Li: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, China
Yangyang Liu: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, China
Feifei Liu: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Xiaojuan Wang: Department of Obstetrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Mengduan Liu: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, China
Wenting Du: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, China
Jing Zhao: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, China
Mengyu Wang: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, China
Liang Hu: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, China
Chuchu Wang: School of Life Sciences, Zhengzhou University, Zhengzhou, 450001, China
Wanrong Fu: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, China
Jianzeng Dong: Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Centre for Cardiovascular Diseases, No. 2 Beijing Anzhen Road, Chaoyang District, Beijing 100029, China; Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, China; Department of Obstetrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Xiaoyan Zhao: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Cardiovascular Institute of Zhengzhou University, Zhengzhou 450052, China; Correspondence author at: Department of Cardiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

Journal volume & issue: Vol. 43

Abstract

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Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiovascular disorder. In this study, we generated human induced pluripotent stem cells (iPSC) ZZUNEUi007-A from dermal fibroblasts of an HCM patient with the p. R663H (c. 1988 G > A) mutation in MYH7. The generated hiPSC line had normal karyotype, showed robust expression of pluripotency markers and could differentiate into all three germ layers in vivo.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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