PLoS ONE (Jan 2016)

Efficacy of Tumor-Targeting Salmonella A1-R on a Melanoma Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Model.

  • Mako Yamamoto,
  • Ming Zhao,
  • Yukihiko Hiroshima,
  • Yong Zhang,
  • Elizabeth Shurell,
  • Fritz C Eilber,
  • Michael Bouvet,
  • Makoto Noda,
  • Robert M Hoffman

DOI
https://doi.org/10.1371/journal.pone.0160882
Journal volume & issue
Vol. 11, no. 8
p. e0160882

Abstract

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Tumor-targeting Salmonella enterica serovar Typhimurium A1-R (Salmonella A1-R) had strong efficacy on a melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse model. GFP-expressing Salmonella A1-R highly and selectively colonized the PDOX melanoma and significantly suppressed tumor growth (p = 0.021). The combination of Salmonella A1-R and cisplatinum (CDDP), both at low-dose, also significantly suppressed the growth of the melanoma PDOX (P = 0.001). Salmonella A1-R has future clinical potential for combination chemotherapy with CDDP of melanoma, a highly-recalcitrant cancer.