Frontiers in Physiology (Jul 2018)

Periodontal Disease and Risk of Bladder Cancer: A Meta-Analysis of 298476 Participants

  • Wen-Zhong Xie,
  • Ying-Hui Jin,
  • Wei-Dong Leng,
  • Xing-Huan Wang,
  • Xing-Huan Wang,
  • Xian-Tao Zeng,
  • Xian-Tao Zeng,
  • Xian-Tao Zeng,
  • Xian-Tao Zeng,
  • BPSC investigators

DOI
https://doi.org/10.3389/fphys.2018.00979
Journal volume & issue
Vol. 9

Abstract

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Objective: It has been reported that the periodontal disease is linked to a number of malignant tumors such as lung cancer and pancreatic cancer. In this study, we aimed to investigate the association of periodontal disease with risk of bladder cancer by a meta-analysis.Methods: PubMed, Scopus, ScienceDirect, and Chinese National Knowledge Infrastructure (CNKI) were searched for eligible publications up to December 15, 2017. Cohort and nested case-control studies on the association between periodontal disease and risk of bladder cancer were included. After study selection and data extraction, pooled hazard ratios (HRs) and their 95% confidence intervals (95%CIs) were calculated using a fixed-effect inverse-variance model. All analyses were performed using the RevMan 5.3 software.Results: Finally, five cohort studies were identified and included in this meta-analysis, involving 1,104 bladder cancer cases of 298,476 participants. Summary estimates based on adjusted data showed that periodontal disease was not significantly associated with the risk of bladder cancer (HR = 1.09, 95% CI = 0.95–1.25, I2 = 0%). A similar result was also observed after cumulative, subgroup and sensitivity analyses.Conclusions: Current evidence from cohort studies suggests that patients with periodontal disease may not be at an increased risk of developing bladder cancer.

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