Journal of Epidemiology (Mar 2023)

Mortality-associated Risk Factors in Hospitalized COVID-19 Patients in Japan: Findings of the CLOT-COVID Study

  • Makoto Takeyama,
  • Sen Yachi,
  • Yuji Nishimoto,
  • Ichizo Tsujino,
  • Junichi Nakamura,
  • Naoto Yamamoto,
  • Hiroko Nakata,
  • Satoshi Ikeda,
  • Michihisa Umetsu,
  • Shizu Aikawa,
  • Hiroya Hayashi,
  • Hirono Satokawa,
  • Yoshinori Okuno,
  • Eriko Iwata,
  • Yoshito Ogihara,
  • Nobutaka Ikeda,
  • Akane Kondo,
  • Takehisa Iwai,
  • Norikazu Yamada,
  • Tomohiro Ogawa,
  • Takao Kobayashi,
  • Makoto Mo,
  • Yugo Yamashita

DOI
https://doi.org/10.2188/jea.JE20220201
Journal volume & issue
Vol. 33, no. 3
pp. 150 – 157

Abstract

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Background: Reports of mortality-associated risk factors in patients with the novel coronavirus disease 2019 (COVID-19) are limited. Methods: We evaluated the clinical features that were associated with mortality among patients who died during hospitalization (n = 158) and those who were alive at discharge (n = 2,736) from the large-scale, multicenter, retrospective, observational cohort CLOT-COVID study, which enrolled consecutively hospitalized COVID-19 patients from 16 centers in Japan from April to September 2021. Data from 2,894 hospitalized COVID-19 participants of the CLOT-COVID study were analyzed in this study. Results: Patients who died were older (71.1 years vs 51.6 years, P 70 years, high D-dimer values on admission, heart disease, active cancer, higher COVID-19 severity on admission, and development of major bleeding during hospitalization were independently associated with a higher mortality risk. Conclusion: This large-scale observational study in Japan identified several independent risk factors for mortality in hospitalized patients with COVID-19 that could facilitate appropriate risk stratification of patients with COVID-19.

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