PLoS ONE (Jan 2018)

How small is TOO small? New liver constraint is needed- Proton therapy of hepatocellular carcinoma patients with small normal liver.

  • Ching-Hsin Lee,
  • Sheng-Ping Hung,
  • Ji-Hong Hong,
  • Joseph Tung-Chieh Chang,
  • Ngan-Ming Tsang,
  • Kun-Ming Chan,
  • Jeng-Hwei Tseng,
  • Shih-Chiang Huang,
  • Shi-Ming Lin,
  • Jau-Min Lien,
  • Nai-Jen Liu,
  • Chen-Chun Lin,
  • Wei-Ting Chen,
  • Wan-Yu Chen,
  • Po-Jui Chen,
  • Bing-Shen Huang

DOI
https://doi.org/10.1371/journal.pone.0203854
Journal volume & issue
Vol. 13, no. 9
p. e0203854

Abstract

Read online

PURPOSE:This study evaluated the outcomes of hepatocellular carcinoma (HCC) patients with small normal liver volume (NLV) treated with proton beam therapy (PBT) and introduced estimated standard liver volume (eSLV) as a new constraint. MATERIALS AND METHODS:HCC patients with NLV 20% and an rV30/eSLV ratio of >30% are acceptable.