Can Immunoexpression of Cancer Stem Cell Markers Prognosticate Tongue Squamous Cell Carcinoma? A Systematic Review and Meta-Analysis

Sayantanee Chaudhury; Swagatika Panda; Neeta Mohanty; Saurav Panda; Diksha Mohapatra; Ravishankar Nagaraja; Alkananda Sahoo; Divya Gopinath; Natalia Lewkowicz; Barbara Lapinska

doi:10.3390/jcm12082753

Journal of Clinical Medicine (Apr 2023)

Can Immunoexpression of Cancer Stem Cell Markers Prognosticate Tongue Squamous Cell Carcinoma? A Systematic Review and Meta-Analysis

Sayantanee Chaudhury,
Swagatika Panda,
Neeta Mohanty,
Saurav Panda,
Diksha Mohapatra,
Ravishankar Nagaraja,
Alkananda Sahoo,
Divya Gopinath,
Natalia Lewkowicz,
Barbara Lapinska

Affiliations

Sayantanee Chaudhury: Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan, Deemed to be University, Bhubaneswar 751003, India
Swagatika Panda: Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan, Deemed to be University, Bhubaneswar 751003, India
Neeta Mohanty: Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan, Deemed to be University, Bhubaneswar 751003, India
Saurav Panda: Department of Periodontics and Implantology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan, Deemed to be University, Bhubaneswar 751003, India
Diksha Mohapatra: Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan, Deemed to be University, Bhubaneswar 751003, India
Ravishankar Nagaraja: Department of Biostatistics, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110021, India
Alkananda Sahoo: Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Siksha ‘O’ Anusandhan, Deemed to be University, Bhubaneswar 751003, India
Divya Gopinath: Basic Medical and Dental Sciences Department, Ajman University, Ajman P.O. Box 346, United Arab Emirates
Natalia Lewkowicz: Department of Periodontology and Oral Diseases, Medical University of Lodz, 251 Pomorska St, 92-213 Lodz, Poland
Barbara Lapinska: Department of General Dentistry, Medical University of Lodz, 251 Pomorska St, 92-213 Lodz, Poland

DOI: https://doi.org/10.3390/jcm12082753
Journal volume & issue: Vol. 12, no. 8
p. 2753

Abstract

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The objective was to evaluate the association of the immunoexpression of cancer stem cell (CSC) markers with clinicopathological and survival outcomes in tongue squamous cell carcinoma (TSCC) patients. This systematic review and meta-analysis [PROSPERO (CRD42021226791)] included observational studies that compared the association of clinicopathological and survival outcomes with CSC immunoexpression in TSCC patients. Pooled odds ratios (ORs) and hazard ratios (HRs) with 95% confidence intervals (CI) were used as outcome measures. Six studies identified the association with three surface markers (c-MET, STAT3, CD44) and four transcription markers (NANOG, OCT4, BMI, SOX2). The odds of early-stage presentation were 41% (OR = 0.59, 95% CI 0.42–0.83) and 75% (OR = 0.25; 95% CI 0.14–0.45) lower in CSC and SOX2 immuno-positive cases than immuno-negative cases, respectively. The odds of well-differentiated tumors in transcription marker immuno-positive cases were 45% lower compared to immuno-negative cases (OR = 0.55, 95% CI 0.32–0.96). The odds of positive lymph nodes were 2.01 times higher in CSC immuno-positive cases compared to immuno-negative cases (OR = 2.01, 95% CI 1.11–3.65). Mortality in immuno-positive cases was 121% higher than that in immuno-negative cases (HR = 2.21; 95% CI 1.16–4.21). Advanced tumor staging and grading, lymph node metastasis, and mortality were significantly associated with positive immunoexpression of CSC markers.

Published in Journal of Clinical Medicine

ISSN: 2077-0383 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine
Website: http://www.mdpi.com/journal/jcm

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