Characterization of polyacrylamide diblock copolymers by mass spectrometry combined with Mass-remainder analysis (MARA)

Tibor Nagy; Akos Kuki; Gergo Roth; Zuura Kaldybek Kyzy; Alifya Balqis Zatalini; David Nyul; Miklos Zsuga; Sandor Keki

Polymer Testing (Jan 2023)

Characterization of polyacrylamide diblock copolymers by mass spectrometry combined with Mass-remainder analysis (MARA)

Tibor Nagy,
Akos Kuki,
Gergo Roth,
Zuura Kaldybek Kyzy,
Alifya Balqis Zatalini,
David Nyul,
Miklos Zsuga,
Sandor Keki

Affiliations

Tibor Nagy: Department of Applied Chemistry, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, H-4032, Debrecen, Hungary
Akos Kuki: Department of Applied Chemistry, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, H-4032, Debrecen, Hungary
Gergo Roth: Department of Applied Chemistry, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, H-4032, Debrecen, Hungary; Doctoral School of Chemistry, University of Debrecen, Egyetem tér 1, H-4032, Debrecen, Hungary
Zuura Kaldybek Kyzy: Department of Applied Chemistry, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, H-4032, Debrecen, Hungary
Alifya Balqis Zatalini: Department of Applied Chemistry, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, H-4032, Debrecen, Hungary
David Nyul: Doctoral School of Chemistry, University of Debrecen, Egyetem tér 1, H-4032, Debrecen, Hungary; Department of Physical Chemistry, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, H-4032, Debrecen, Hungary
Miklos Zsuga: Department of Applied Chemistry, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, H-4032, Debrecen, Hungary
Sandor Keki: Department of Applied Chemistry, Faculty of Science and Technology, University of Debrecen, Egyetem tér 1, H-4032, Debrecen, Hungary; Corresponding Author.

Journal volume & issue: Vol. 117
p. 107834

Abstract

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Polyacrylamide block copolymers has been extensively used in many fields of science and technology due to their water solubility, biocompatibility and smart and tunable properties. In this study, we used the Mass-remainder analysis (MARA) and the Multi-step Mass-remainder analysis (M-MARA) for the processing of complex MALDI-TOF mass spectra of a series of poly(N-acryloylmorpholine)-block-poly(N-isopropylacrylamide) diblock copolymers. It was found that selection of the MARA base mass unit affects the shape of the Mass remainder versus m/z plots enabling to draw conclusions about the length and diversity of the blocks. Even better and more informative visualization can be achieved by creating 2-step M-MARA plots. The comprehensive characterization of the poly(N-acryloylmorpholine)-block-poly(N-isopropylacrylamide) copolymers with various block length were performed, and the results were confirmed by nuclear magnetic resonance (NMR) spectroscopy.

Published in Polymer Testing

ISSN: 0142-9418 (Print); 1873-2348 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Chemical technology: Polymers and polymer manufacture
Website: https://www.journals.elsevier.com/polymer-testing

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