Budding uninhibited by benzimidazoles 1 promotes cell proliferation, invasion, and epithelial-mesenchymal transition via the Wnt/β-catenin signaling in glioblastoma

Jinshi Zhang; Wenjin Wei; Qinglin Zhong; Kaiming Feng; Ruijin Yang; Qiuhua Jiang

Heliyon (Jun 2023)

Budding uninhibited by benzimidazoles 1 promotes cell proliferation, invasion, and epithelial-mesenchymal transition via the Wnt/β-catenin signaling in glioblastoma

Jinshi Zhang,
Wenjin Wei,
Qinglin Zhong,
Kaiming Feng,
Ruijin Yang,
Qiuhua Jiang

Affiliations

Jinshi Zhang: Department of Neurosurgery, The Affiliated Ganzhou Hospital of Nanchang University, Ganzhou 341000, China
Wenjin Wei: Department of Neurosurgery, The Affiliated Ganzhou Hospital of Nanchang University, Ganzhou 341000, China
Qinglin Zhong: Department of Neurosurgery, The Affiliated Ganzhou Hospital of Nanchang University, Ganzhou 341000, China
Kaiming Feng: Corresponding author.; Department of Neurosurgery, The Affiliated Ganzhou Hospital of Nanchang University, Ganzhou 341000, China
Ruijin Yang: Department of Neurosurgery, The Affiliated Ganzhou Hospital of Nanchang University, Ganzhou 341000, China
Qiuhua Jiang: Department of Neurosurgery, The Affiliated Ganzhou Hospital of Nanchang University, Ganzhou 341000, China

Journal volume & issue: Vol. 9, no. 6
p. e16996

Abstract

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The pathogenesis and progression of GBM (glioblastoma), as one of the most frequently occurring malignancies of the central nervous system, are regulated by several genes. BUB1 (budding uninhibited by benzimidazoles 1) is a mitotic checkpoint that plays an important role in chromosome segregation as well as in various tumors. However, its role in glioma is unknown. The current study discovered prominently elevated BUB1 in glioma and a significant relationship between BUB1 expression, a high World Health Organization grade, and a poor prognosis in glioma patients. Moreover, BUB1 triggered EMT (epithelial-mesenchymal transition) apart from promoting glioma cell proliferation, migration, and infiltration. Besides, BUB1 promoted EMT by activating the Wnt/β-catenin axis. As implied by our study, BUB1 probably has the potential as a target for GBM management.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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