Nature Communications (Nov 2020)

Ni-catalyzed asymmetric hydrogenation of N-aryl imino esters for the efficient synthesis of chiral α-aryl glycines

  • Dan Liu,
  • Bowen Li,
  • Jianzhong Chen,
  • Ilya D. Gridnev,
  • Deyue Yan,
  • Wanbin Zhang

DOI
https://doi.org/10.1038/s41467-020-19807-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 9

Abstract

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Chiral α-amino acids find application in the fields of pharmaceutical, biological and synthetic chemistry. Here, the authors report a nickel-catalyzed asymmetric hydrogenation of N-aryl imino esters affording chiral α-aryl glycines in high yields and enantioselectivities.