Communications Medicine (Mar 2023)
Plasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma
- Abhinav Srinath,
- Bingqing Xie,
- Ying Li,
- Je Yeong Sone,
- Sharbel Romanos,
- Chang Chen,
- Anukriti Sharma,
- Sean Polster,
- Pieter C. Dorrestein,
- Kelly C. Weldon,
- Dorothy DeBiasse,
- Thomas Moore,
- Rhonda Lightle,
- Janne Koskimäki,
- Dongdong Zhang,
- Agnieszka Stadnik,
- Kristina Piedad,
- Matthew Hagan,
- Abdallah Shkoukani,
- Julián Carrión-Penagos,
- Dehua Bi,
- Le Shen,
- Robert Shenkar,
- Yuan Ji,
- Ashley Sidebottom,
- Eric Pamer,
- Jack A. Gilbert,
- Mark L. Kahn,
- Mark D’Souza,
- Dinanath Sulakhe,
- Issam A. Awad,
- Romuald Girard
Affiliations
- Abhinav Srinath
- Neurovascular Surgery Program, Department of Neurological Surgery, The University of Chicago, 5841S. Maryland Avenue
- Bingqing Xie
- Department of Medicine, University of Chicago
- Ying Li
- Neurovascular Surgery Program, Department of Neurological Surgery, The University of Chicago, 5841S. Maryland Avenue
- Je Yeong Sone
- Neurovascular Surgery Program, Department of Neurological Surgery, The University of Chicago, 5841S. Maryland Avenue
- Sharbel Romanos
- Neurovascular Surgery Program, Department of Neurological Surgery, The University of Chicago, 5841S. Maryland Avenue
- Chang Chen
- Bioinformatics Core, Center for Research Informatics, The University of Chicago
- Anukriti Sharma
- Department of Surgery, The University of Chicago, 5841 S. Maryland Avenue
- Sean Polster
- Neurovascular Surgery Program, Department of Neurological Surgery, The University of Chicago, 5841S. Maryland Avenue
- Pieter C. Dorrestein
- Department of Pediatrics, The University of California San Diego and Scripps Institution of Oceanography
- Kelly C. Weldon
- Department of Pediatrics, The University of California San Diego and Scripps Institution of Oceanography
- Dorothy DeBiasse
- Neurovascular Surgery Program, Department of Neurological Surgery, The University of Chicago, 5841S. Maryland Avenue
- Thomas Moore
- Neurovascular Surgery Program, Department of Neurological Surgery, The University of Chicago, 5841S. Maryland Avenue
- Rhonda Lightle
- Neurovascular Surgery Program, Department of Neurological Surgery, The University of Chicago, 5841S. Maryland Avenue
- Janne Koskimäki
- Neurovascular Surgery Program, Department of Neurological Surgery, The University of Chicago, 5841S. Maryland Avenue
- Dongdong Zhang
- Neurovascular Surgery Program, Department of Neurological Surgery, The University of Chicago, 5841S. Maryland Avenue
- Agnieszka Stadnik
- Neurovascular Surgery Program, Department of Neurological Surgery, The University of Chicago, 5841S. Maryland Avenue
- Kristina Piedad
- Neurovascular Surgery Program, Department of Neurological Surgery, The University of Chicago, 5841S. Maryland Avenue
- Matthew Hagan
- Neurovascular Surgery Program, Department of Neurological Surgery, The University of Chicago, 5841S. Maryland Avenue
- Abdallah Shkoukani
- Neurovascular Surgery Program, Department of Neurological Surgery, The University of Chicago, 5841S. Maryland Avenue
- Julián Carrión-Penagos
- Neurovascular Surgery Program, Department of Neurological Surgery, The University of Chicago, 5841S. Maryland Avenue
- Dehua Bi
- Department of Public Health Sciences, University of Chicago
- Le Shen
- Neurovascular Surgery Program, Department of Neurological Surgery, The University of Chicago, 5841S. Maryland Avenue
- Robert Shenkar
- Neurovascular Surgery Program, Department of Neurological Surgery, The University of Chicago, 5841S. Maryland Avenue
- Yuan Ji
- Department of Public Health Sciences, University of Chicago
- Ashley Sidebottom
- Host-Microbe Metabolomics Facility, Duchossois Family Institute, University of Chicago
- Eric Pamer
- Host-Microbe Metabolomics Facility, Duchossois Family Institute, University of Chicago
- Jack A. Gilbert
- Department of Surgery, The University of Chicago, 5841 S. Maryland Avenue
- Mark L. Kahn
- Department of Medicine and Cardiovascular Institute, University of Pennsylvania
- Mark D’Souza
- Host-Microbe Metabolomics Facility, Duchossois Family Institute, University of Chicago
- Dinanath Sulakhe
- Host-Microbe Metabolomics Facility, Duchossois Family Institute, University of Chicago
- Issam A. Awad
- Neurovascular Surgery Program, Department of Neurological Surgery, The University of Chicago, 5841S. Maryland Avenue
- Romuald Girard
- Neurovascular Surgery Program, Department of Neurological Surgery, The University of Chicago, 5841S. Maryland Avenue
- DOI
- https://doi.org/10.1038/s43856-023-00265-1
- Journal volume & issue
-
Vol. 3,
no. 1
pp. 1 – 15
Abstract
Srinath, Xie et al. analyze plasma metabolites present in patients with cerebral cavernous angiomas. Cholic acid and hypoxanthine are found in those with Cavernous Angioma disease whilst arachidonic and linoleic acids are found in Cavernous Angioma patients with symptomatic hemorrhage.
