Luteapyrone, a Novel ƴ-Pyrone Isolated from the Filamentous Fungus <i>Metapochonia lutea</i>
Roman Labuda,
Markus Bacher,
Hannes Gratzl,
Maria Doppler,
Alexandra Parich,
Mohammed Aufy,
Rosa Lemmens-Gruber,
Rainer Schuhmacher,
Kathrin Rychli,
Martin Wagner,
Thomas Rosenau,
Joseph Strauss,
Christoph Schüller
Affiliations
Roman Labuda
Unit of Food Microbiology, Department for Farm Animals and Veterinary Public Health, Institute of Food Safety, Food Technology and Veterinary Public Health, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria
Markus Bacher
Core Facility Bioactive Molecules, Screening and Analysis and Research Platform Bioactive Microbial Metabolites (BiMM), Konrad Lorenz Strasse 24, 3430 Tulln an der Donau, Austria
Hannes Gratzl
Core Facility Bioactive Molecules, Screening and Analysis and Research Platform Bioactive Microbial Metabolites (BiMM), Konrad Lorenz Strasse 24, 3430 Tulln an der Donau, Austria
Maria Doppler
Core Facility Bioactive Molecules, Screening and Analysis and Research Platform Bioactive Microbial Metabolites (BiMM), Konrad Lorenz Strasse 24, 3430 Tulln an der Donau, Austria
Alexandra Parich
Department of Agrobiotechnology (IFA-Tulln), Institute of Bioanalytics and Agro-Metabolomics, University of Natural Resources and Life Sciences, Vienna (BOKU), Konrad Lorenz Strasse 20, 3430 Tulln an der Donau, Austria
Mohammed Aufy
Department for Pharmacology and Toxicology, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria
Rosa Lemmens-Gruber
Department for Pharmacology and Toxicology, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria
Rainer Schuhmacher
Core Facility Bioactive Molecules, Screening and Analysis and Research Platform Bioactive Microbial Metabolites (BiMM), Konrad Lorenz Strasse 24, 3430 Tulln an der Donau, Austria
Kathrin Rychli
Unit of Food Microbiology, Department for Farm Animals and Veterinary Public Health, Institute of Food Safety, Food Technology and Veterinary Public Health, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria
Martin Wagner
Unit of Food Microbiology, Department for Farm Animals and Veterinary Public Health, Institute of Food Safety, Food Technology and Veterinary Public Health, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria
Thomas Rosenau
Department of Chemistry, University of Natural Resources and Life Sciences, Vienna (BOKU), Konrad Lorenz Strasse 24, 3430 Tulln an der Donau, Austria
Joseph Strauss
Core Facility Bioactive Molecules, Screening and Analysis and Research Platform Bioactive Microbial Metabolites (BiMM), Konrad Lorenz Strasse 24, 3430 Tulln an der Donau, Austria
Christoph Schüller
Core Facility Bioactive Molecules, Screening and Analysis and Research Platform Bioactive Microbial Metabolites (BiMM), Konrad Lorenz Strasse 24, 3430 Tulln an der Donau, Austria
In the process of screening for new bioactive microbial metabolites we found a novel ƴ-pyrone derivative for which we propose the trivial name luteapyrone, in a recently described microscopic filamentous fungus, Metapochonia lutea BiMM-F96/DF4. The compound was isolated from the culture extract of the fungus grown on modified yeast extract sucrose medium by means of flash chromatography followed by preparative HPLC. The chemical structure was elucidated by NMR and LC-MS. The new compound was found to be non-cytotoxic against three mammalian cell lines (HEK 263, KB-3.1 and Caco-2). Similarly, no antimicrobial activity was observed in tested microorganisms (gram positive and negative bacteria, yeast and fungi).
