Nature Communications (Oct 2020)

Sensing of autoinducer-2 by functionally distinct receptors in prokaryotes

  • Lei Zhang,
  • Shuyu Li,
  • Xiaozhen Liu,
  • Zhuo Wang,
  • Mei Jiang,
  • Ruiying Wang,
  • Laigong Xie,
  • Qinmeng Liu,
  • Xiaorong Xie,
  • Daohan Shang,
  • Mengyun Li,
  • Zhiyan Wei,
  • Yao Wang,
  • Chengpeng Fan,
  • Zhao-Qing Luo,
  • Xihui Shen

DOI
https://doi.org/10.1038/s41467-020-19243-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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The small molecule AI-2 acts as a quorum sensing signal, mediating communication within and between many bacterial species. Here, the authors identify a new type of AI-2 receptor, consisting of a dCACHE domain that is present in many bacterial and archaeal proteins.