Nature Communications (Jul 2020)
Non-invasive early detection of cancer four years before conventional diagnosis using a blood test
- Xingdong Chen,
- Jeffrey Gole,
- Athurva Gore,
- Qiye He,
- Ming Lu,
- Jun Min,
- Ziyu Yuan,
- Xiaorong Yang,
- Yanfeng Jiang,
- Tiejun Zhang,
- Chen Suo,
- Xiaojie Li,
- Lei Cheng,
- Zhenhua Zhang,
- Hongyu Niu,
- Zhe Li,
- Zhen Xie,
- Han Shi,
- Xiang Zhang,
- Min Fan,
- Xiaofeng Wang,
- Yajun Yang,
- Justin Dang,
- Catie McConnell,
- Juan Zhang,
- Jiucun Wang,
- Shunzhang Yu,
- Weimin Ye,
- Yuan Gao,
- Kun Zhang,
- Rui Liu,
- Li Jin
Affiliations
- Xingdong Chen
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University
- Jeffrey Gole
- Singlera Genomics Inc.
- Athurva Gore
- Singlera Genomics Inc.
- Qiye He
- Singlera Genomics (Shanghai) Ltd.
- Ming Lu
- Taizhou Institute of Health Sciences, Fudan University
- Jun Min
- Singlera Genomics Inc.
- Ziyu Yuan
- Taizhou Institute of Health Sciences, Fudan University
- Xiaorong Yang
- Taizhou Institute of Health Sciences, Fudan University
- Yanfeng Jiang
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University
- Tiejun Zhang
- Department of Epidemiology, School of Public Health, Fudan University
- Chen Suo
- Department of Epidemiology, School of Public Health, Fudan University
- Xiaojie Li
- Singlera Genomics (Shanghai) Ltd.
- Lei Cheng
- Singlera Genomics (Shanghai) Ltd.
- Zhenhua Zhang
- Singlera Genomics (Shanghai) Ltd.
- Hongyu Niu
- Singlera Genomics (Shanghai) Ltd.
- Zhe Li
- Singlera Genomics (Shanghai) Ltd.
- Zhen Xie
- Singlera Genomics (Shanghai) Ltd.
- Han Shi
- Singlera Genomics Inc.
- Xiang Zhang
- Taizhou Disease Control and Prevention Center
- Min Fan
- Taixing Disease Control and Prevention Center
- Xiaofeng Wang
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University
- Yajun Yang
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University
- Justin Dang
- Singlera Genomics Inc.
- Catie McConnell
- Singlera Genomics Inc.
- Juan Zhang
- Taizhou Institute of Health Sciences, Fudan University
- Jiucun Wang
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University
- Shunzhang Yu
- Taizhou Institute of Health Sciences, Fudan University
- Weimin Ye
- Taizhou Institute of Health Sciences, Fudan University
- Yuan Gao
- Singlera Genomics Inc.
- Kun Zhang
- Department of Bioengineering, University of California at San Diego
- Rui Liu
- Singlera Genomics Inc.
- Li Jin
- State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University
- DOI
- https://doi.org/10.1038/s41467-020-17316-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 10
Abstract
Patients whose disease is diagnosed in its early stages have better outcomes. In this study, the authors develop a non invasive blood test based on circulating tumor DNA methylation that can potentially detect cancer occurrence even in asymptomatic patients.
