Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction

Leonardo P. de Carvalho, MD, PhD; Sock Hwee Tan, PhD; Ghim-Siong Ow, BSc; Zhiqun Tang, PhD; Jianhong Ching, PhD; Jean-Paul Kovalik, MD, PhD; Sock Cheng Poh, BSc; Chee-Tang Chin, MBBS; A. Mark Richards, MD, PhD; Eliana C. Martinez, MD, PhD; Richard W. Troughton, MD, PhD; Alan Yean-Yip Fong, MBBS; Bryan P. Yan, MBBS; Aruni Seneviratna, MBBS, MPH; Vitaly Sorokin, MD, PhD; Scott A. Summers, PhD; Vladimir A. Kuznetsov, PhD, SciD; Mark Y. Chan, MBBS, PhD

JACC: Basic to Translational Science (Apr 2018)

Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction

Leonardo P. de Carvalho, MD, PhD,
Sock Hwee Tan, PhD,
Ghim-Siong Ow, BSc,
Zhiqun Tang, PhD,
Jianhong Ching, PhD,
Jean-Paul Kovalik, MD, PhD,
Sock Cheng Poh, BSc,
Chee-Tang Chin, MBBS,
A. Mark Richards, MD, PhD,
Eliana C. Martinez, MD, PhD,
Richard W. Troughton, MD, PhD,
Alan Yean-Yip Fong, MBBS,
Bryan P. Yan, MBBS,
Aruni Seneviratna, MBBS, MPH,
Vitaly Sorokin, MD, PhD,
Scott A. Summers, PhD,
Vladimir A. Kuznetsov, PhD, SciD,
Mark Y. Chan, MBBS, PhD

Affiliations

Leonardo P. de Carvalho, MD, PhD: Federal University of Sao Paulo State, Sao Paulo, Brazil; National University Heart Center, Singapore, Singapore; Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Albert Einstein Hospital, São Paulo, Brazil
Sock Hwee Tan, PhD: National University Heart Center, Singapore, Singapore; Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Ghim-Siong Ow, BSc: Bioinformatics Institute, A*STAR, Singapore
Zhiqun Tang, PhD: Bioinformatics Institute, A*STAR, Singapore; Institute of Molecular and Cell Biology, A*STAR, Singapore
Jianhong Ching, PhD: Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, Singapore
Jean-Paul Kovalik, MD, PhD: Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, Singapore
Sock Cheng Poh, BSc: National University Heart Center, Singapore, Singapore
Chee-Tang Chin, MBBS: Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, Singapore; National Heart Centre Singapore, Singapore
A. Mark Richards, MD, PhD: National University Heart Center, Singapore, Singapore; Christchurch Heart Institute, University of Otago Christchurch, Christchurch Hospital, Christchurch, New Zealand
Eliana C. Martinez, MD, PhD: Miller School of Medicine, University of Miami, Miami, Florida
Richard W. Troughton, MD, PhD: Christchurch Heart Institute, University of Otago Christchurch, Christchurch Hospital, Christchurch, New Zealand
Alan Yean-Yip Fong, MBBS: Clinical Research Centre, Sarawak General Hospital, Kuching, Malaysia; Department of Cardiology, Sarawak General Hospital, Kuching, Malaysia
Bryan P. Yan, MBBS: Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China
Aruni Seneviratna, MBBS, MPH: National University Heart Center, Singapore, Singapore
Vitaly Sorokin, MD, PhD: National University Heart Center, Singapore, Singapore; Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Scott A. Summers, PhD: University of Utah, Salt Lake City, Utah
Vladimir A. Kuznetsov, PhD, SciD: Bioinformatics Institute, A*STAR, Singapore; Nanyang Institute of Technology in Health & Medicine, Nanyang Technological University, Singapore; Dr. Vladimir A. Kuznetsov, Department of Urology, Department of Biochemistry and Molecular Biology, 750 East Adams Street, Weiskotten Hall, Room 1271, SUNY Upstate Medical University, Syracuse, New York 13210.
Mark Y. Chan, MBBS, PhD: National University Heart Center, Singapore, Singapore; Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Address for correspondence: Dr. Mark Y. Chan, Cardiac Department, Yong Loo-Lin School of Medicine, National University of Singapore, 1E, Kent Ridge Road, NUHS Tower Block, Level 9, Singapore 119228.

Journal volume & issue: Vol. 3, no. 2
pp. 163 – 175

Abstract

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Summary: We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without recent AMI, showed a significant increase in 5 of the signature’s 12 ceramides in plasma but not simultaneously-biopsied aortic tissue. In contrast, a rat AMI model, compared with sham control, showed a significant increase in myocardial concentrations of all 12 ceramides and up-regulation of 3 ceramide-producing enzymes, suggesting ischemic myocardium as a possible source of this ceramide signature. Key Words: acute coronary syndrome, ceramides, dihydroceramides, major adverse cardiovascular and cerebrovascular events, prognosis, risk prediction

Published in JACC: Basic to Translational Science

ISSN: 2452-302X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-basic-to-translational-science/

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