Jichu yixue yu linchuang (Nov 2022)

Puerarin attenuates LPS-induced renal inflammatory response of mice

  • FENG Na, TANG Jie, HE Xi-ju, TIAN Zong-ying, SHI Dan-dan, YU Jing-jing

DOI
https://doi.org/10.16352/j.issn.1001-6325.2022.11.1727
Journal volume & issue
Vol. 42, no. 11
pp. 1727 – 1730

Abstract

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Objective To investigate whether puerarin (PUE) can alleviate lipopolysarccharide(LPS)-induced renal inflammatory response in mice. Methods Thirty health control, 45 severe infection with no renal injury(N-SI group), 30 severe infection with renal injury(SI group) were enrolled in this study, Serum samples were collected. 50 mice were randomly divided into 5 groups, including control(Ctrl) group, LPS group, and LPS+PUE(10, 25, 50 mg/kg·d, IP) groups. PUE was applied 1 h after LPS administration. And mice were sacrificed after 24 h and blood sample was collected. MDA, SOD, IL-33 and IL-6 expression were detected by ELISA. Results BUN, Scr, IL-6 and IL-33 in SI group were significantly increased compared with control group and N-SI group (P＜0.05). BUN and Scr of LPS group were significantly increased compared with control group. PUE decreased BUN, Scr, MDA, IL-33 and IL-6 expression and increased activity of SOD as compared with LPS group(P＜0.05). Conclusions PUE can alleviate LPS-induced renal inflammatory response in mice.

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