Nature Communications (Jul 2022)
PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus
- E. R. Velasco,
- A. Florido,
- Á Flores,
- E. Senabre,
- A. Gomez-Gomez,
- A. Torres,
- A. Roca,
- S. Norrholm,
- E. L. Newman,
- P. Das,
- R. A. Ross,
- A. Lori,
- O. J. Pozo,
- K. J. Ressler,
- L. L. Garcia-Esteve,
- T. Jovanovic,
- R. Andero
Affiliations
- E. R. Velasco
- Institut de Neurociències, Universitat Autònoma de Barcelona
- A. Florido
- Institut de Neurociències, Universitat Autònoma de Barcelona
- Á Flores
- Institut de Neurociències, Universitat Autònoma de Barcelona
- E. Senabre
- Laboratory of Neuropharmacology-NeuroPhar, Department of Experimental and Health Sciences, University Pompeu Fabra
- A. Gomez-Gomez
- Integrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute)
- A. Torres
- Perinatal Mental health Unit, Department of Psychiatry and Clinical Psychology, Institute of Neuroscience, Hospital Clínic, IDIBAPS
- A. Roca
- Perinatal Mental health Unit, Department of Psychiatry and Clinical Psychology, Institute of Neuroscience, Hospital Clínic, IDIBAPS
- S. Norrholm
- Department of Psychiatry and Behavioral Neuroscience, Wayne State University
- E. L. Newman
- McLean Hospital, Department of Psychiatry, Harvard Medical School
- P. Das
- Department of Neuroscience, Albert Einstein College of Medicine, Psychiatry Research Institute of Montefiore and Einstein
- R. A. Ross
- Department of Neuroscience, Albert Einstein College of Medicine, Psychiatry Research Institute of Montefiore and Einstein
- A. Lori
- Department of Psychiatry & Behavioral Sciences, Emory University
- O. J. Pozo
- Integrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute)
- K. J. Ressler
- McLean Hospital, Department of Psychiatry, Harvard Medical School
- L. L. Garcia-Esteve
- Perinatal Mental health Unit, Department of Psychiatry and Clinical Psychology, Institute of Neuroscience, Hospital Clínic, IDIBAPS
- T. Jovanovic
- Department of Psychiatry and Behavioral Neuroscience, Wayne State University
- R. Andero
- Departament de Psicobiologia i de Metodologia de les Ciències de la Salut, Universitat Autònoma de Barcelona
- DOI
- https://doi.org/10.1038/s41467-022-31442-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
The PACAP-PAC1R neuropeptide system regulates neuroendocrine stress responses. Here the authors demonstrate a role for PACAP-PAC1R in ventromedial hypothalamus in modulating fear extinction.
