In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives

Mostafa M. Ghorab; Mansour S. Alsaid; Mohammed S. Al-Dosari; Marwa G. El-Gazzar; Ahmed H. Arbab

doi:10.3390/molecules21040409

Molecules (Mar 2016)

In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives

Mostafa M. Ghorab,
Mansour S. Alsaid,
Mohammed S. Al-Dosari,
Marwa G. El-Gazzar,
Ahmed H. Arbab

Affiliations

Mostafa M. Ghorab: Department of Pharmacognosy, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia
Mansour S. Alsaid: Department of Pharmacognosy, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia
Mohammed S. Al-Dosari: Department of Pharmacognosy, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia
Marwa G. El-Gazzar: Department of Drug Radiation Research, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Nasr City, Cairo 113701, Egypt
Ahmed H. Arbab: Department of Pharmacognosy, College of Pharmacy, King Saud University, P. O. Box 2457, Riyadh 11451, Saudi Arabia

DOI: https://doi.org/10.3390/molecules21040409
Journal volume & issue: Vol. 21, no. 4
p. 409

Abstract

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A novel series of sulfonamide derivatives (14 compounds) bearing thiourea moieties were efficiently synthesized and evaluated for their possible in vitro anticancer activity against four human tumor cell lines. The results indicated that compound 6 was the most potent, showing effectiveness on all the tested cell lines. Compounds 7 and 10 also showed promising results.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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