A high rate of CLL phenotype lymphocytes in autoimmune hemolytic anemia and immune thrombocytopenic purpura

Abstract

Minor CLL-like clones are found in ~3% of healthy individuals. AIHA and ITP are common in CLL and may be causally linked. We investigated the presence of CLL phenotype lymphocytes in 11 cases of primary AIHA, 18 of ITP and 2 of Evans’ Syndrome, compared with 26 age-matched healthy controls. A population of ‘CLL phenotype’ was seen in 6/31 patients compared to 1/26 healthy controls (χ2=3.9; p=0.05). Such clones may be important in the pathogenesis of autoimmune blood disorders.