Cell cycle arrest: a key point of AKI-to-CKD transition

Abstract

As the major threat of poor renal outcome and survival quality, the mechanism of acute kidneyinjury (AKI) progressing to chronic kidney disease (CKD) has aroused much attention. The cell cycle arrest, one ofthe major culprits, accelerates the AKI-to-CKD transition through maladaptive repair that involved overwhelmingcytokines excretion and inflammation storm, epithelial-mesenchymal transition, organelles stress/crosstalk,aging activation as well as peritubular capillary rarefaction. Therefore, the cell cycle regulation can serve as anovel potential therapeutic target for the prevention, alleviation and even interruption of AKI -to- CKD transition.

Keywords

• cell cycle arrest
• g2/m phase
• acute kidney injury
• chronic kidney disease
• maladaptive repair