TNF-α is a Novel Biomarker for Predicting Plaque Rupture in Patients with ST-Segment Elevation Myocardial Infarction

Abstract

Xing Luo,1,2 Chen Zhao,1,2 Shengfang Wang,1,2 Haibo Jia,1,2 Bo Yu1,2 1Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, People’s Republic of China; 2Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin Medical University, Harbin, 150001, People’s Republic of ChinaCorrespondence: Haibo Jia; Bo Yu, Tel/Fax [phone], Email [email protected]; [email protected] and Aims: Patients with plaque rupture (PR) present with different cardiovascular risks, clinical strategies, and outcomes from those with plaque erosion (PE). However, there are lack of noninvasive biomarkers to distinguish PE from PR.Methods: A prospective analysis of 382 patients with ST-segment elevation myocardial infarction (STEMI) was conducted. Of these patients, 262 and 120 presented with PR and PE, respectively. An additional 83 patients diagnosed with stable angina pectoris were enrolled as control group. Peripheral blood monocytes were collected pre-percutaneous coronary intervention and used to evaluate the mRNA expression of IL-4, IL-10, IL-1β, and TNF-α in all patients.Results: STEMI patients had higher IL-4, IL-10, IL-1β, and TNF-α expression than the control patients. The mRNA levels of IL-4, IL-1β, and TNF-α were significantly higher in PR patients than PE; however, no significant difference was observed in IL-10 between PE and PR. The areas under the receiver-operating characteristic curves for IL-4, IL-1β, and TNF-α for PR versus PE were 0.685, 0.747, and 0.895, respectively. At the cut-off value of 2.52, TNF-α demonstrated a sensitivity of 70.61% and specificity of 93.33% for discriminating PR from PE patients. When added to the model of established clinical risk factors, TNF-α significantly improved the predictive accuracy of PR. Multivariable logistic regression analysis indicated that TNF-α mRNA level was independently associated with PR (odds ratio, 3.09; 95% confidence interval, 2.29– 4.16; p < 0.001).Conclusion: The inflammatory response of peripheral blood mononuclear cells in patients with PR was higher than that in patients with PE. TNF-α may be a potential biomarker for predicting PR that could facilitate risk stratification and management in STEMI patients.Graphical Abstract: Keywords: acute coronary syndrome, plaque rupture, plaque erosion, inflammation, TNF-α

Keywords

• acute coronary syndrome
• plaque rupture
• plaque erosion
• inflammation
• tnf-α