A multi-centric dataset on patient-individual pathological lymph node involvement in head and neck squamous cell carcinoma
Roman Ludwig,
Adrian Schubert,
Dorothea Barbatei,
Laurence Bauwens,
Sandrine Werlen,
Olgun Elicin,
Matthias Dettmer,
Philippe Zrounba,
Panagiotis Balermpas,
Bertrand Pouymayou,
Vincent Grégoire,
Roland Giger,
Jan Unkelbach
Affiliations
Roman Ludwig
Department of Radiation Oncology, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland; Corresponding author.
Adrian Schubert
Department of ENT, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 18, CH-3010 Bern, Switzerland; Head and Neck Anticancer Center, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 18, CH-3010 Bern, Switzerland; Department of ENT, Head and Neck Surgery, Réseau Hospitalier Neuchâtelois (RHNe), Maladière 45, CH-2000 Neuchâtel, Switzerland
Dorothea Barbatei
Department of Radiation Oncology, Centre Léon Bérard, 28 Rue Laennec, 69008 Lyon, France
Laurence Bauwens
Department of Radiation Oncology, Centre Léon Bérard, 28 Rue Laennec, 69008 Lyon, France
Sandrine Werlen
Department of ENT, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 18, CH-3010 Bern, Switzerland; Head and Neck Anticancer Center, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 18, CH-3010 Bern, Switzerland
Olgun Elicin
Department of Radiation Oncology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 18, CH-3010 Bern, Switzerland
Matthias Dettmer
Institute of Pathology, Klinikum Stuttgart, Kriegsbergstr. 60c, 70174 Stuttgart, Germany; Institute of Tissue Medicine and Pathology, University of Bern, Murtenstrasse 31, 3008 Bern, Switzerland
Philippe Zrounba
Department of Head and Neck surgery, Centre Léon Bérard, 28 Rue Laennec, 69008 Lyon, France
Panagiotis Balermpas
Department of Radiation Oncology, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland
Bertrand Pouymayou
Department of Radiation Oncology, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland
Vincent Grégoire
Department of Radiation Oncology, Centre Léon Bérard, 28 Rue Laennec, 69008 Lyon, France
Roland Giger
Department of ENT, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 18, CH-3010 Bern, Switzerland; Head and Neck Anticancer Center, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 18, CH-3010 Bern, Switzerland
Jan Unkelbach
Department of Radiation Oncology, University Hospital Zurich, Rämistrasse 100, 8091 Zurich, Switzerland
Dataset: We provide a dataset on lymph node metastases in 968 patients with newly diagnosed head and neck squamous cell carcinoma (HNSCC). All patients received neck dissection and we report the number of metastatic versus investigated lymph nodes per lymph node level (LNL) for every individual patient. Additionally, clinicopathological factors including T-category, primary tumor subsite (ICD-O-3 code), age, and sex are reported for all patients. The data is provided as three datasets: Dataset 1 contains 373 HNSCC patients treated at Centre Léon Bérard (CLB), France, with primary tumor location in the oral cavity, oropharynx, hypopharynx, and larynx. Dataset 2 contains 332 HNSCC patients treated at the Inselspital, Bern University Hospital (ISB), Switzerland with primary tumor location in the oral cavity, oropharynx, hypopharynx, and larynx. For these patients, additional information is provided including lateralization of the primary tumor, size and location of the largest metastases, and clinical involvement based on computed tomography (CT), magnetic resonance imaging (MRI), and/or 18FDG-positron emission tomography (PET/CT) imaging. Dataset 3 consists of 263 oropharyngeal SCC patients underlying a previous publication by Bauwens et al. [1], which were treated at CLB. For these patients, additional information including HPV status, lateralization of the primary tumor and clinically diagnosed lymph node involvement is provided. Reuse Potential: The data may be used to quantify the probability of occult lymph node metastases in each LNL, depending on an individual patient's characteristics of the primary tumor and the location of clinically diagnosed lymph node metastases. As such, the data may contribute to further personalize the elective treatment of the neck for HNSCC patients, i.e. definition of the elective clinical target volume (CTV-N) in radiotherapy (RT) and the extent of neck dissection (ND) in surgery. There exists only one similar publicly available dataset that reports clinical involvement per LNL in 287 oropharyngeal SCC patients [2]. The data presented in this article substantially extends the available data, it additionally includes pathologically assessed involvement per LNL, and it provides data for multiple subsites in the head and neck region.
