Nature Communications (Oct 2018)

Broad phylogenetic analysis of cation/proton antiporters reveals transport determinants

  • Gal Masrati,
  • Manish Dwivedi,
  • Abraham Rimon,
  • Yael Gluck-Margolin,
  • Amit Kessel,
  • Haim Ashkenazy,
  • Itay Mayrose,
  • Etana Padan,
  • Nir Ben-Tal

DOI
https://doi.org/10.1038/s41467-018-06770-5
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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Cation/proton antiporters (CPAs) play a major role in maintaining living cells’ homeostasis and are divided in two main groups: CPA1 and CPA2. Here authors use a comprehensive evolutionary analysis of 6537 representative CPAs and reveal a sequence motif that determines central phenotypic characteristics.