Scaffold Hopping to Imidazo[1,2‑a]pyrazin-8-one Positive Allosteric Modulators of Metabotropic Glutamate 2 Receptor

• Ana I. de Lucas,
• Juan A. Vega,
• Aránzazu García Molina,
• María Lourdes Linares,
• Gary Tresadern,
• Hilde Lavreysen,
• Daniel Oehlrich,
• Andrés A. Trabanco,
• José M. Cid

Affiliations

Ana I. de Lucas

Discovery Chemistry, Discovery Sciences, Janssen Research & Development, Division of Janssen-Cilag S.A., Toledo, Spain

Juan A. Vega

Discovery Chemistry, Discovery Sciences, Janssen Research & Development, Division of Janssen-Cilag S.A., Toledo, Spain

Aránzazu García Molina

Discovery Chemistry, Discovery Sciences, Janssen Research & Development, Division of Janssen-Cilag S.A., Toledo, Spain

María Lourdes Linares

Discovery Chemistry, Discovery Sciences, Janssen Research & Development, Division of Janssen-Cilag S.A., Toledo, Spain

Gary Tresadern

Computational Chemistry, Discovery Sciences, Janssen Research & Development, Division of Janssen Pharmaceutica N.V., Beerse, Belgium

Hilde Lavreysen

Clinical Research and Development, Janssen Pharmaceutica N.V., Beerse, Belgium

Daniel Oehlrich

Discovery Chemistry, Discovery Sciences, Janssen Research & Development, Division of Janssen Pharmaceutica N.V., Beerse, Belgium

Andrés A. Trabanco

Discovery Chemistry, Discovery Sciences, Janssen Research & Development, Division of Janssen-Cilag S.A., Toledo, Spain

José M. Cid

Discovery Chemistry, Discovery Sciences, Janssen Research & Development, Division of Janssen-Cilag S.A., Toledo, Spain