Nature Communications (Apr 2017)
DNA single-strand break-induced DNA damage response causes heart failure
- Tomoaki Higo,
- Atsuhiko T. Naito,
- Tomokazu Sumida,
- Masato Shibamoto,
- Katsuki Okada,
- Seitaro Nomura,
- Akito Nakagawa,
- Toshihiro Yamaguchi,
- Taku Sakai,
- Akihito Hashimoto,
- Yuki Kuramoto,
- Masamichi Ito,
- Shungo Hikoso,
- Hiroshi Akazawa,
- Jong-Kook Lee,
- Ichiro Shiojima,
- Peter J. McKinnon,
- Yasushi Sakata,
- Issei Komuro
Affiliations
- Tomoaki Higo
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
- Atsuhiko T. Naito
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
- Tomokazu Sumida
- CREST
- Masato Shibamoto
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
- Katsuki Okada
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
- Seitaro Nomura
- CREST
- Akito Nakagawa
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
- Toshihiro Yamaguchi
- Department of Cardiovascular Medicine, The University of Tokyo Graduate School of Medicine
- Taku Sakai
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
- Akihito Hashimoto
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
- Yuki Kuramoto
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
- Masamichi Ito
- Department of Cardiovascular Medicine, The University of Tokyo Graduate School of Medicine
- Shungo Hikoso
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
- Hiroshi Akazawa
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
- Jong-Kook Lee
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
- Ichiro Shiojima
- CREST
- Peter J. McKinnon
- Department of Genetics and Tumor Cell Biology, ST. Jude Children’s Research Hospital
- Yasushi Sakata
- Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
- Issei Komuro
- CREST
- DOI
- https://doi.org/10.1038/ncomms15104
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
DNA damage response (DDR) is activated in cardiomyocytes of the failing heart, but the type of DNA damage leading to DDR is unclear. Higoet al. show that in mice heart failure is caused in part by unrepaired DNA single-strand breaks in cardiomyocytes, which activate persistent DDR and trigger an NF-κB-dependent cardiac inflammation.
