Nature Communications (Jul 2016)
Glycolytic regulation of cell rearrangement in angiogenesis
- Bert Cruys,
- Brian W. Wong,
- Anna Kuchnio,
- Dries Verdegem,
- Anna Rita Cantelmo,
- Lena-Christin Conradi,
- Saar Vandekeere,
- Ann Bouché,
- Ivo Cornelissen,
- Stefan Vinckier,
- Roeland M. H. Merks,
- Elisabetta Dejana,
- Holger Gerhardt,
- Mieke Dewerchin,
- Katie Bentley,
- Peter Carmeliet
Affiliations
- Bert Cruys
- Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism
- Brian W. Wong
- Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism
- Anna Kuchnio
- Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism
- Dries Verdegem
- Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism
- Anna Rita Cantelmo
- Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism
- Lena-Christin Conradi
- Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism
- Saar Vandekeere
- Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism
- Ann Bouché
- Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism
- Ivo Cornelissen
- Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism
- Stefan Vinckier
- Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism
- Roeland M. H. Merks
- Life Sciences Group, Centrum Wiskunde and Informatica
- Elisabetta Dejana
- Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University
- Holger Gerhardt
- Department of Oncology, Vascular Patterning Laboratory
- Mieke Dewerchin
- Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism
- Katie Bentley
- Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University
- Peter Carmeliet
- Department of Oncology, Laboratory of Angiogenesis and Vascular Metabolism
- DOI
- https://doi.org/10.1038/ncomms12240
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 15
Abstract
Glycolytic regulator PFKFB3 is a key player in vessel sprouting. Here the authors develop a computational model predicting that PFKFB3 drives endothelial cell rearrangement during vessel sprouting by promoting filopodia formation and reducing intercellular adhesion, and empirically validate this prediction.
