Use of trifluoroacetaldehyde N-tfsylhydrazone as a trifluorodiazoethane surrogate and its synthetic applications

Xinyu Zhang; Zhaohong Liu; Xiangyu Yang; Yuanqing Dong; Matteo Virelli; Giuseppe Zanoni; Edward A. Anderson; Xihe Bi

doi:10.1038/s41467-018-08253-z

Nature Communications (Jan 2019)

Use of trifluoroacetaldehyde N-tfsylhydrazone as a trifluorodiazoethane surrogate and its synthetic applications

Xinyu Zhang,
Zhaohong Liu,
Xiangyu Yang,
Yuanqing Dong,
Matteo Virelli,
Giuseppe Zanoni,
Edward A. Anderson,
Xihe Bi

Affiliations

Xinyu Zhang: Department of Chemistry, Northeast Normal University
Zhaohong Liu: Department of Chemistry, Northeast Normal University
Xiangyu Yang: Department of Chemistry, Northeast Normal University
Yuanqing Dong: Department of Chemistry, Northeast Normal University
Matteo Virelli: Department of Chemistry, University of Pavia
Giuseppe Zanoni: Department of Chemistry, University of Pavia
Edward A. Anderson: Chemistry Research Laboratory, University of Oxford
Xihe Bi: Department of Chemistry, Northeast Normal University

DOI: https://doi.org/10.1038/s41467-018-08253-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

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Since fluoro-compounds are popular in industrial settings, efficient methods for incorporation of fluoride into organic molecules are desirable. Here, the authors developed trifluoroacetaldehyde N-tfsylhydrazone (TFHZ-Tfs) as a CF3CHN2 surrogate that generates CF3CHN2 in situ under basic conditions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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