International Journal of COPD (Sep 2022)
Correlation Analysis of Early Renal Injury in Elderly Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Abstract
Dong Zhang Department of Internal Medicine, The Second Hospital of Beijing, Beijing, 100031, People’s Republic of ChinaCorrespondence: Dong Zhang, Department of Internal Medicine, The Second Hospital of Beijing, No. 36 of Youfang Hutong, Xicheng District, Beijing, 100031, People’s Republic of China, Tel +86 10 66061122, Email [email protected]: To investigate the correlation between serum cystatin C (Cys-C) and beta-2 (β 2) microglobulin (β 2-MG) levels and renal injury in elderly patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD) with a view to detecting renal injury in its early stages.Methods: A total of 106 patients with AECOPD were enrolled and divided into three groups according to their oxygen partial pressure (PO2) levels: severe hypoxia group, moderate hypoxia group, and mild hypoxia group. Another 60 healthy subjects were selected as the control group. General clinical data were collected from all the study subjects, along with measurements of arterial blood gas, Cys-C, β 2-MG, serum creatinine (Scr), urea nitrogen (BUN), partial pressure of carbon dioxide (PCO2), and high-sensitivity C-reactive protein (hs-CRP).Results: The levels of hs-CRP, Cys-C, β 2-MG, Scr, and BUN were highest in the severe hypoxia group, followed by the moderate hypoxia group, then the mild hypoxia group, and lowest in the control group. The differences between the groups were statistically significant for these indicators (P 0.05). The levels of Cys-C and β 2-MG were positively correlated with the levels of hs-CRP, PCO2, Scr, and BUN and negatively correlated with PO2 levels. hs-CRP and PO2 were high-risk factors influencing Cys-C levels, and β 2-MG was a risk factor influencing Cys-C levels. The level of PO2 was a high-risk factor influencing β 2-MG levels, and PCO2 and Cys-C were risk factors influencing β 2-MG levels.Conclusion: Renal injury was found to be present in patients with AECOPD and worsened with increasing degrees of hypoxia. Hypoxia and inflammation might be risk factors for renal injury in patients with AECOPD, Cys-C and β 2-MG could be sensitive indicators for the early detection of renal injury.Keywords: cystatin C, β 2 microglobulin, acute exacerbations of chronic obstructive pulmonary disease, early renal injury
