Nature Communications (Sep 2020)
Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis
- Lang Rao,
- Lei Wu,
- Zhida Liu,
- Rui Tian,
- Guocan Yu,
- Zijian Zhou,
- Kuikun Yang,
- Hong-Gang Xiong,
- Anli Zhang,
- Guang-Tao Yu,
- Wenjing Sun,
- Han Xu,
- Jingya Guo,
- Andrew Li,
- Hongmin Chen,
- Zhi-Jun Sun,
- Yang-Xin Fu,
- Xiaoyuan Chen
Affiliations
- Lang Rao
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
- Lei Wu
- State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University
- Zhida Liu
- Department of Pathology, University of Texas Southwestern Medical Center
- Rui Tian
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
- Guocan Yu
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
- Zijian Zhou
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
- Kuikun Yang
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
- Hong-Gang Xiong
- State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University
- Anli Zhang
- Department of Pathology, University of Texas Southwestern Medical Center
- Guang-Tao Yu
- State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University
- Wenjing Sun
- Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
- Han Xu
- Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
- Jingya Guo
- Chinese Academy of Sciences Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences
- Andrew Li
- Department of Biomedical Engineering, Johns Hopkins University
- Hongmin Chen
- Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University
- Zhi-Jun Sun
- State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University
- Yang-Xin Fu
- Department of Pathology, University of Texas Southwestern Medical Center
- Xiaoyuan Chen
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-020-18626-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 13
Abstract
The application of STING agonists and the blockade of the SIRPα–CD47 signaling axis are emerging immunotherapeutic strategies. Here the authors show that hybrid cellular membrane nanovesicles loaded with a STING agonist or overexpressing high-affinity SIRPα variants can be exploited to promote anti-tumor immune responses.
