Efficacy of statin therapy in reducing epicardial adipose tissue: a systematic review and meta-analysis

Abstract

Introduction Understanding the effect of statins on epicardial adipose tissue (EAT) is important as it may help reduce the negative impact of EAT-derived molecules on the cardiovascular system and consequently on coronary artery disease. Thus, we aimed to perform a systematic review and meta-analysis to assess the impact of statin therapy on EAT. Methods The study utilized Scopus, PubMed, Embase, and Web of Science to gather relevant studies on the impacts of statins on EAT until September 5th, 2023. The data collected underwent meta-analysis using Comprehensive Meta-Analysis (CMA) V4 software. Results In the meta-analysis, three studies involving 512 subjects were ultimately incorporated. The findings indicated a significant decrease in EAT after treatment with statins (standardized mean difference (SMD = –0.507, 95% CI: –2.536, 1.521, p = 0.021). Conclusions Statins appear to exert an additional cardiovascular therapeutic effect by reducing EAT.

Keywords

• epicardial adipose tissue
• cardiovascular disease
• coronary artery disease
• statin
• systematic review