Porcine skin ablation using mid-infrared picosecond pulse burst

Wenjie Yue; Yongchang Zhang; Libing Shi; Tao Chen; Jianmin Chen; Bo Wu; Songying Zhang; Rong Shu; Yonghang Shen

Results in Optics (Dec 2022)

Porcine skin ablation using mid-infrared picosecond pulse burst

Wenjie Yue,
Yongchang Zhang,
Libing Shi,
Tao Chen,
Jianmin Chen,
Bo Wu,
Songying Zhang,
Rong Shu,
Yonghang Shen

Affiliations

Wenjie Yue: Key Laboratory of Space Active Opto-Electronics Technology, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China; State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China
Yongchang Zhang: State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China
Libing Shi: Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Runrun Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China
Tao Chen: Key Laboratory of Space Active Opto-Electronics Technology, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China
Jianmin Chen: Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province, Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Runrun Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China
Bo Wu: State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China
Songying Zhang: State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China
Rong Shu: Key Laboratory of Space Active Opto-Electronics Technology, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China; Corresponding authors.
Yonghang Shen: State Key Laboratory of Modern Optical Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China; Corresponding authors.

Journal volume & issue: Vol. 9
p. 100309

Abstract

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We present the porcine skin ablation using a mid-infrared high-repetition-rate picosecond pulse burst laser. A burst-mode pulse with a repetition rate of 16.32 MHz was generated from a home-built difference frequency generation (DFG) system operating at 3 μm. Within each burst, there were 16 equally spaced 8.5 ps sub-pulses at an intra-burst repetition rate of ∼3.3 GHz. To study the laser-tissue interaction, laser powers of 1 to 2 W, and scanning times from 1 to 10 with spot size of ∼50 μm were applied to irradiate the fresh porcine skin. The results demonstrate that the burst-mode pulse with modest peak power density of MW/cm2 is efficient for tissue ablation. The optimized ablation depth increased with the average power and scanning times, reaching a maximal incision depth of 150 μm. Thanks to the high repetition rate of intra-burst pulse and high absorption of radiation, the ablation width and thermal effect width kept within 50 μm and 25 μm in all control groups. It is believed that as the first demonstration, such mid-infrared burst-mode laser radiation with modest power intensity is of great potential to realize micron penetration depth and low thermal effect in high-precision surgery applications.

Published in Results in Optics

ISSN: 2666-9501 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Physics: Optics. Light
Website: https://www.journals.elsevier.com/results-in-optics

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