Histological and Nanomechanical Properties of a New Nanometric Hydroxiapatite Implant Surface. An In Vivo Study in Diabetic Rats
Paula G. F. P. Oliveira,
Paulo G. Coelho,
Edmara T. P. Bergamo,
Lukasz Witek,
Cristine A. Borges,
Fábio B. Bezerra,
Arthur B. Novaes,
Sergio L. S. Souza
Affiliations
Paula G. F. P. Oliveira
Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Av do Café, s/n., Ribeirao Preto, SP 14040-904, Brazil
Paulo G. Coelho
Hansjorg Wyss Department of Plastic Surgery, New York University School of Medicine, New York, NY 10010, USA
Edmara T. P. Bergamo
Department of Prosthodontic and Periodontology, Bauru School of Dentistry, University of Sao Paulo, Av. Octavio Pinheiro Brisolla9-75, Bauru, SP 17012-901, Brazil
Lukasz Witek
Department of Biomaterials and Biomimetics, New York University College of Dentistry, New York, NY 10010, USA
Cristine A. Borges
Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Av do Café, s/n., Ribeirao Preto, SP 14040-904, Brazil
Fábio B. Bezerra
Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Av do Café, s/n., Ribeirao Preto, SP 14040-904, Brazil
Arthur B. Novaes
Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Av do Café, s/n., Ribeirao Preto, SP 14040-904, Brazil
Sergio L. S. Souza
Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Av do Café, s/n., Ribeirao Preto, SP 14040-904, Brazil
Implant therapy is a predictable treatment to replace missing teeth. However, the osseointegration process may be negatively influenced by systemic conditions, such as diabetes mellitus (DM). Microtopography and implant surface developments are strategies associated to better bone repair. This study aimed to evaluate, in healthy and diabetic rats, histomorphometric (bone to implant contact = %BIC; and bone area fraction occupancy = %BAFO) and nanomechanical (elastic modulus = EM; and hardness = H) bone parameters, in response to a nanometric hydroxyapatite implant surface. Mini implants (machined = MAC; double acid etched = DAE, and with addition of nano-hydroxyapatite = NANO) were installed in tibias of healthy and diabetic rats. The animals were euthanized at 7 and 30 days. NANO surface presented higher %BIC and %BAFO when compared to MAC and DAE (data evaluated as a function of implant surface). NANO surface presented higher %BIC and %BAFO, with statistically significant differences (data as a function of time and implant surface). NANO surface depicted higher EM and H values, when compared to machined and DAE surfaces (data as a function of time and implant surface). Nano-hydroxyapatite coated implants presented promising biomechanical results and could be an important tool to compensate impaired bone healing reported in diabetics.