NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance

Xiaoguang Li; Zhida Liu; Anli Zhang; Chuanhui Han; Aijun Shen; Lingxiang Jiang; David A. Boothman; Jian Qiao; Yang Wang; Xiumei Huang; Yang-Xin Fu

doi:10.1038/s41467-019-11238-1

Nature Communications (Jul 2019)

NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance

Xiaoguang Li,
Zhida Liu,
Anli Zhang,
Chuanhui Han,
Aijun Shen,
Lingxiang Jiang,
David A. Boothman,
Jian Qiao,
Yang Wang,
Xiumei Huang,
Yang-Xin Fu

Affiliations

Xiaoguang Li: Department of Pathology, University of Texas Southwestern Medical Center
Zhida Liu: Department of Pathology, University of Texas Southwestern Medical Center
Anli Zhang: Department of Pathology, University of Texas Southwestern Medical Center
Chuanhui Han: Department of Pathology, University of Texas Southwestern Medical Center
Aijun Shen: Department of Pathology, University of Texas Southwestern Medical Center
Lingxiang Jiang: Department of Radiation Oncology, Simon Cancer Center, Indiana University School of Medicine
David A. Boothman: Department of Biochemistry and Molecular Biology, Simon Cancer Center, Indiana University School of Medicine
Jian Qiao: Department of Pathology, University of Texas Southwestern Medical Center
Yang Wang: Department of Pathology, University of Texas Southwestern Medical Center
Xiumei Huang: Department of Radiation Oncology, Simon Cancer Center, Indiana University School of Medicine
Yang-Xin Fu: Department of Pathology, University of Texas Southwestern Medical Center

DOI: https://doi.org/10.1038/s41467-019-11238-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

Read online

Improper innate sensing within the tumor microenvironment limits immunotherapy success. Here, the authors show that targeting NQO1 triggers immunogenic innate sensing to reactivate T cells and overcome immune checkpoint blockade resistance.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal