Mantle cell lymphoma presenting with lethal atraumatic splenic rupture

Frederick  Eyerer; Juli-Anne  Gardner; Katherine A.  Devitt

Autopsy and Case Reports (Nov 2021)

Mantle cell lymphoma presenting with lethal atraumatic splenic rupture

Frederick Eyerer,
Juli-Anne Gardner,
Katherine A. Devitt

Affiliations

Frederick Eyerer: University of Vermont Medical Center, Department of Pathology and Laboratory Medicine, Burlington, VT, USA
Juli-Anne Gardner: University of Vermont Medical Center, Department of Pathology and Laboratory Medicine, Burlington, VT, USA
Katherine A. Devitt: University of Vermont Medical Center, Department of Pathology and Laboratory Medicine, Burlington, VT, USA

Journal volume & issue: Vol. 11

Abstract

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Mantle cell lymphoma is characterized by t(11;14) with CCND1-IGH fusion and manifests with a spectrum of disease ranging from relatively indolent to aggressive. Here, we present a case of pleomorphic mantle cell lymphoma with three fusion signals that presented with lethal atraumatic splenic rupture. We discuss on the implications of variant CCND1 signal patterns as well as the epidemiology and pathophysiology of atraumatic splenic rupture.

Published in Autopsy and Case Reports

ISSN: 2236-1960 (Online)
Publisher: University of São Paulo
Country of publisher: Brazil
LCC subjects: Medicine: Internal medicine
Website: http://www.autopsyandcasereports.org

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Abstract

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