Paired electrolysis-enabled nickel-catalyzed enantioselective reductive cross-coupling between α-chloroesters and aryl bromides

Dong Liu; Zhao-Ran Liu; Zhen-Hua Wang; Cong Ma; Simon Herbert; Hartmut Schirok; Tian-Sheng Mei

doi:10.1038/s41467-022-35073-z

Nature Communications (Nov 2022)

Paired electrolysis-enabled nickel-catalyzed enantioselective reductive cross-coupling between α-chloroesters and aryl bromides

Dong Liu,
Zhao-Ran Liu,
Zhen-Hua Wang,
Cong Ma,
Simon Herbert,
Hartmut Schirok,
Tian-Sheng Mei

Affiliations

Dong Liu: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, CAS
Zhao-Ran Liu: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, CAS
Zhen-Hua Wang: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, CAS
Cong Ma: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, CAS
Simon Herbert: Pharmaceuticals, Research and Development, Bayer AG
Hartmut Schirok: Pharmaceuticals, Research and Development, Bayer AG
Tian-Sheng Mei: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, CAS

DOI: https://doi.org/10.1038/s41467-022-35073-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 9

Abstract

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Precise matching of reaction rate and electric potential of electrodes in paired electrolysis is challenging. Here, the authors develop paired-electrolysis-enabled nickel-catalyzed enantioselective reductive cross-coupling of α-chloroesters and aryl bromides.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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