Nature Communications (Dec 2019)

Natural selection favoring more transmissible HIV detected in United States molecular transmission network

  • Joel O. Wertheim,
  • Alexandra M. Oster,
  • William M. Switzer,
  • Chenhua Zhang,
  • Nivedha Panneer,
  • Ellsworth Campbell,
  • Neeraja Saduvala,
  • Jeffrey A. Johnson,
  • Walid Heneine

DOI
https://doi.org/10.1038/s41467-019-13723-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 10

Abstract

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Here, the authors use a molecular epidemiological approach to investigate the frequency and intensity of clustering of HIV with different set-point viral loads and find that frequently transmitted strains in genetic transmission clusters have significantly higher viral loads than nonclustered viruses.