Gasdermins: novel mitochondrial pore-forming proteins

Abstract

Gasdermin proteins have been extensively characterized for their ability to form necrotic pores in the plasma membrane, however, their interactions with other organelles have yet to be described. We recently demonstrated that some gasdermin proteins can also permeabilize the mitochondria to augment apoptotic signaling which may be important in the context of cancer and hearing loss.

Keywords

• gasdermin
• gsdmd
• gsdme
• dfna5
• caspase-3
• apoptosis
• pyroptosis
• mitochondria
• cytochrome c
• inflammasome