Nature Communications (May 2017)
Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania
- Tom Parks,
- Mariana M. Mirabel,
- Joseph Kado,
- Kathryn Auckland,
- Jaroslaw Nowak,
- Anna Rautanen,
- Alexander J. Mentzer,
- Eloi Marijon,
- Xavier Jouven,
- Mai Ling Perman,
- Tuliana Cua,
- John K. Kauwe,
- John B. Allen,
- Henry Taylor,
- Kathryn J. Robson,
- Charlotte M. Deane,
- Andrew C. Steer,
- Adrian V. S. Hill,
- Pacific Islands Rheumatic Heart Disease Genetics Network
Affiliations
- Tom Parks
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Mariana M. Mirabel
- Paris Centre de Recherche Cardiovasculaire, Institut National de la Santé et de la Recherche Médicale, Hôpital Européen Georges Pompidou
- Joseph Kado
- Department of Paediatrics, Ministry of Health and Medical Services, Colonial War Memorial Hospital
- Kathryn Auckland
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Jaroslaw Nowak
- Department of Statistics, University of Oxford
- Anna Rautanen
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Alexander J. Mentzer
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Eloi Marijon
- Paris Centre de Recherche Cardiovasculaire, Institut National de la Santé et de la Recherche Médicale, Hôpital Européen Georges Pompidou
- Xavier Jouven
- Paris Centre de Recherche Cardiovasculaire, Institut National de la Santé et de la Recherche Médicale, Hôpital Européen Georges Pompidou
- Mai Ling Perman
- College of Medicine, Nursing & Health Sciences, Fiji National University
- Tuliana Cua
- Rheumatic Heart Disease Control Programme, Ministry of Health and Medical Services, Colonial War Memorial Hospital
- John K. Kauwe
- College of Life Sciences, Brigham Young University
- John B. Allen
- College of Life Sciences, Brigham Young University
- Henry Taylor
- Rheumatic Heart Disease Control Programme, Samoa Ministry of Health
- Kathryn J. Robson
- MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Headington
- Charlotte M. Deane
- Department of Statistics, University of Oxford
- Andrew C. Steer
- Centre for International Child Health, University of Melbourne
- Adrian V. S. Hill
- Wellcome Trust Centre for Human Genetics, University of Oxford
- Pacific Islands Rheumatic Heart Disease Genetics Network
- DOI
- https://doi.org/10.1038/ncomms14946
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 10
Abstract
Rheumatic heart disease (RHD) is a chronic auto-inflammatory reaction to group A streptococcal infection, and frequently occurs in individuals from the South Pacific. This study finds a novel association between an immunoglobulin heavy chain allele and risk of RHD in Pacific Islanders and South Asians.
