Journal of Experimental & Clinical Cancer Research (Mar 2012)

IgD multiple myeloma a descriptive report of 17 cases: survival and response to therapy

  • Pisani Francesco,
  • Petrucci Maria Teresa,
  • Giannarelli Diana,
  • Bongarzoni Velia,
  • Montanaro Marco,
  • De Stefano Valerio,
  • La Verde Giacinto,
  • Gentilini Fabiana,
  • Levi Anna,
  • Za Tommaso,
  • Moscetti Alessandro,
  • Annino Luciana,
  • Petti Maria Concetta

DOI
https://doi.org/10.1186/1756-9966-31-17
Journal volume & issue
Vol. 31, no. 1
p. 17

Abstract

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Abstract Background Immunoglobulin D multiple myeloma (MM) is rare and has a poorer prognosis than other MM isotypes. Design and methods Seventeen patients (pts) diagnosed from 1993 to 2009 with IgD MM were selected from six institutions of Multiple Myeloma Latium-Region GIMEMA Working Group. Results Median age was 55 years, 14 patients had bone lesions, eight had renal impairment with estimated glomerular filtration rate (eGFR) Conclusions Despite the retrospective analysis and the small number of pts our study showed that the use of HDT/ASCT seems to improve also the prognosis of IgD MM patients. Treatment options including new drugs, before and after stem cell transplantation, may further improve the outcomes of these patients.