Organocatalytic enantioselective dearomatization of thiophenes by 1,10-conjugate addition of indole imine methides

Xingguang Li; Meng Duan; Peiyuan Yu; K. N. Houk; Jianwei Sun

doi:10.1038/s41467-021-25165-7

Nature Communications (Aug 2021)

Organocatalytic enantioselective dearomatization of thiophenes by 1,10-conjugate addition of indole imine methides

Xingguang Li,
Meng Duan,
Peiyuan Yu,
K. N. Houk,
Jianwei Sun

Affiliations

Xingguang Li: Department of Chemistry, the Hong Kong University of Science and Technology, Clear Water Bay, Kowloon
Meng Duan: Department of Chemistry and Biochemistry, University of California, Los Angeles
Peiyuan Yu: Department of Chemistry and Shenzhen Grubbs Institute, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology
K. N. Houk: Department of Chemistry and Biochemistry, University of California, Los Angeles
Jianwei Sun: Department of Chemistry, the Hong Kong University of Science and Technology, Clear Water Bay, Kowloon

DOI: https://doi.org/10.1038/s41467-021-25165-7
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 10

Abstract

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Catalytic asymmetric dearomatization is a powerful tool for the rapid construction of diverse chiral cyclic molecules from cheap and easily available arenes. Here the authors show an organocatalytic enantioselective dearomatization of substituted thiophenes in the context of a rare remote asymmetric 1,10-conjugate addition.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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