Current and Future Perspectives for Chimeric Antigen Receptor T Cells Development in Poland

Abstract

Chimeric antigen receptor T (CAR-T) cells are genetically modified autologous T cells that have revolutionized the treatment of relapsing and refractory haematological malignancies. In this review we present molecular pathways involved in the activation of CAR-T cells, describe in details the structures of receptors and the biological activity of CAR-T cells currently approved for clinical practice in the European Union, and explain the functional differences between them. Finally, we present the potential for the development of CAR-T cells in Poland, as well as indicate the possible directions of future research in this area, including novel modifications and applications of CAR-T cells and CAR-natural killer (NK) cells.

Keywords

• CAR-T
• CAR-NK
• chimeric antigen receptor
• tisagenlecleucel
• axicabtagene ciloleucel
• brexucabtagene autoleucel