p53 contributes to the chemotherapeutic drug doxorubicininduced cell death in colorectal cancer cell line HCT116

Abstract

Doxorubicin is a commonly used chemotherapy drug for cancer treatment, but its effectiveness varies across different cancer types. p53 is a key factor involved in cell death induced by therapeutic agents. It can be upregulated by Doxorubicin and have a function of apoptosis. To have a further study of the mechanism between p53 and Doxorubicin, we investigated whether p53 play a role in the doxorubicininduced cell death in the colorectal cancer line HCT116. Our finding revealed that p53 was upregulated in HCT116 cells when treated with doxorubicin, and knockdown of p53 decreased the sensitivity of HCT116 cells to doxorubicin. These results suggest that p53 plays an important role in doxorubicin-induced cell death in HCT116 cells, which could contribute to more effective treatment approaches.